COVID-19 has already overwhelmed health systems in high-income countries. As it spreads to fragile and crisisaffected countries, it threatens even greater devastation. There is a small window left to mount a robust response while COVID-19 is still in the early stages of spreading to these settings. COVID-19 is a global threat requiring a global response, but the steps to contain it should be designed locally, particularly in the crisis settings where the International Rescue Committee (IRC) works, to avoid exacerbating humanitarian suffering.